Intensive Lifestyle Modification for CAD Reversal Successfully Reduces Research Paper

Intensive Lifestyle Modification for CAD Reversal Successfully Reduces Circulating Levels of Metabolic Hormones Insulin and Leptin - Research Paper Example of the deaths reported from United States due to Coronary vascular disease is also 30 and this is reported maximum for the age groups above 65 (United States, 2006) Among various pathogenic factors, insulin resistance and visceral obesity are considered most significant. (Duvnjak and Duvnjak, 19- 24) . The observed metabolic abnormalities are due to insulin resistance in muscles and surrounding adipose tissue along with the adverse impact on tissue by compensatory hyperinsulinaemia, which is insulin sensitive (Duvnjak and Duvnjak, 19- 24). In addition, abdominal adiposity is also considered a high risk for cardio vascular diseases (CVD). Also, the increasing obesity is found to decrease adiponectin that has important cardiometabolic actions (Bray et al, 30-40). Significant breakthroughs have also been achieved in understanding the key initiators for coronary artery disease. The initiation and progression of atherosclerosis has been found to be associated with leptin. Studies have also shown that plasma leptin concentration has direct relation to the incidence of coronory artery disease and thus could be used as a risk indicator for the developm ent of the disease (Dubey et al, 124 - 128). . It is clear that the role played by obesity in the cardiometabolic risk is very vital for the development of treatment strategies for the patients with a high risk for cardio vascular diseases (CVD).A critical role played by adipocytokines between insulin resistance and cardiovascular disease has been established. It is also anticipated that effective interventions to improve the functions of endothelial or adipose tissues could significantly reduce the occurrence of cardiovascular events in the obese individuals with metabolic syndrome (Hamdy, 231 - 241). One of the effective ways to treat the people with high cardiovascular risk is through the various lifestyle modifications like restricted calorie intake and increased physical activity (Hamdy, 231-241). The impact of