Running Head: HYPOPLASTIC LEFT HEART SYNDROME
Hypoplastic Left breast Syndrome
Hypoplastic 2
Hypoplastic left(p) heart syndrome (HLHS) is congenital abnormality in which the left grimace of the heart is severely underdeveloped. It is often associated with mitral atresia, aortal atresia, or both (http://www.accessmedicine.com, 2008). When the left-side heart structures are underdeveloped, the refine side of the heart must pump blood to both the lungs and to the quiet of the body. In HLHS, pulmonary venous blood enters the left atrium notwithstanding systole is unable to push the blood across the stenotic or absent mitral valve into the left ventricle. The blood instead is shunted into the right atrium through the PDA, where it contributes to volume loading of the right ventricle. The end military issue is pulmonary venous hypertension, right ventricular failure, and profound underperfusion of coronary thrombosis arteries and vital organs (http://www.accessmedicine.com, 2008).
Despite remarkable advances in the diagnosis and treatment of HLHS, it remains one of the most therapeutically gainsay and least-understood forms of congenital heart disease. HLHS is a rare defect, occurring in 0.016%-0.
036% of function births (Bove, 2002). However, it continues to be the leading cause of infant death callable to cardiovascular malformation (CVM) and is associated with significant long-term morbidity (JACC, 2007).
During the last 50 years there has been increasing evidence that supports a genetic etiology for HLHS. In the Journal of the American College of Cardiology, Hinton et al performed a study to determine the size of heritability in families set by a HLHS proband. They found that HLHS was almost exclusively the resolution of a genetic cause. Fifty-five per centum of the families had 1 or more affected family members and rate among siblings was 8%. Twenty-two percent of the siblings also had an additional CVM....If you want to get a blanket(a) essay, order it on our website: Ordercustompaper.com
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