Olivopontocerebellar Atrophy Essay -- Health Medicine Medical Essays

Olivopontocerebellar wastingAbstract Olivopontocerebellar wither(OPCA), is characterized by neuronal retroversion of the cerebellar cortex, the insufficient olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is commonly seen with OPCA. Current research is focusing on three primary systems thinking to be responsible for the etiology of OPCA. They are excitatory amino group group loony toons disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the reversion of neurons in the cerebellar cortex, pons, and substandard olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, w hich usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. fit in to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, cachexy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15). Biopsies on maintenance OPCA patients have suggested that there are n... ...cerebellar atrophy. Annals of Neurology, 26362-367, 1989. 12. Kish, S., Robitaille, Y., El-Awar, M. et. al. Brain amino acidulent reductions in one family with chromosome 6p-linked dominantly inherited olivoponto cerebellar atrophy. Annals of Neurology, 30780-784, 1991. 13.Landis, D., Rosenburg, R., Landis, S. et. al. Olivopontocerebellar degeneration. narrative of Neurology, 31295--307, 1974. 14. Makowiec, R., Albin, R., Cha, J-H. et. al. Two types of quisqualate receptors are decreased in human olivopontocerebellar atrophy cerebellar cortex. Brain Research, 523309-312, 1990. 15. Merritt, Houston. A Textbook of Neurology. Lea and Febiger, Philadelphia. 1967 16. Nakazato, Y., Yamazaki, H., Hirato, J. et. al. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. journal of Neuropathology and Experimental Neurology, 49521-530, 1990. Olivopontocerebellar Atrophy Essay -- Health Medicine medical checkup EssaysOlivopontocerebellar AtrophyAbstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbance s in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on three primary systems suasion to be responsible for the etiology of OPCA. They are excitatory amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. harmonize to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number o f neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15). Biopsies on aliveness OPCA patients have suggested that there are n... ...cerebellar atrophy. Annals of Neurology, 26362-367, 1989. 12. Kish, S., Robitaille, Y., El-Awar, M. et. al. Brain amino acid reductions in one family with chromosome 6p-linked dominantly inherited olivopontocerebellar atrophy. Annals of Neurology, 30780-784, 1991. 13.Landis, D., Rosenburg, R., Landis, S. et. al. Olivopontocerebellar degeneration. memorial of Neurology, 31295--307, 1974. 14. Makowiec, R., Albin, R., Cha, J-H. et. al. Two types of quisqualate receptors are decreased in human olivop ontocerebellar atrophy cerebellar cortex. Brain Research, 523309-312, 1990. 15. Merritt, Houston. A Textbook of Neurology. Lea and Febiger, Philadelphia. 1967 16. Nakazato, Y., Yamazaki, H., Hirato, J. et. al. Oligodendroglial microtubular tangles in olivopontocerebellar atrophy. diary of Neuropathology and Experimental Neurology, 49521-530, 1990.